I just dropped a video on Rumble that might change how you think about longevity forever.
And I'm not being dramatic.
Let me explain.
Most people are stuck on the surface.
Supplements. Hormones. Even peptides.
All of these are incredible tools. I've built my entire platform around them.
But here's the truth nobody talks about:
They're all signaling tools.
They knock on the door and ask your body to respond.
Bioregulators?
They walk in, sit down at the control panel, and start adjusting the settings.
Here's the difference in one sentence:
Peptides = software updates.
Bioregulators = rebuilding the hardware.
One stimulates. The other restores.
And that distinction matters more than most people realize.
So what actually ARE bioregulators?
Short version:
They're extremely small chains of amino acids — so small they can enter the cell nucleus and influence how your DNA expresses itself.
Read that again.
They don't just stimulate a receptor like peptides do.
They help restore how an organ produces its own protective and regenerative proteins.
Why does size matter?
Most peptides are too large to enter the nucleus.
They bind to receptors on the outside of cells and trigger a response.
Bioregulators are only 2-4 amino acids long.
That's small enough to slip past the cell membrane, enter the nucleus, and interact directly with your DNA.
This is called gene expression modulation.
Instead of telling your body what to do from the outside, bioregulators remind your organs how to function optimally from the inside.
Here's what makes them different from anything else:
1. They're organ-specific.
Each bioregulator is derived from and targets a specific organ system:
Cardiogen → Heart tissue
Cortagen → Brain and nervous system
Pinealon → Pineal gland (sleep/melatonin)
Thymalin → Thymus (immune system)
Vesugen → Blood vessels
Pancragen → Pancreas (blood sugar regulation)
Livagen → Liver
Testagen → Testes (men's hormonal health)
You're not blasting your whole system. You're precisely restoring ONE organ at a time.
2. The effects last long after you stop.
This is the wild part.
Because bioregulators restore how an organ functions — not just how it responds — the benefits continue for months after your cycle ends.
The organ is actually healthier. Not just stimulated.
3. They've been researched for 40+ years.
Bioregulators were developed in Russia by Professor Vladimir Khavinson starting in the 1980s.
His research spans over 40 years with extensive clinical studies.
This isn't new. It's just new to the West.
FYI, Biolongevity Labs is running their End of Year Sale right now. 40% off all peptide and bioregulator vials, plus an additional 15% off when you use code LEE15 at checkout.
The protocol is stupidly simple.
Every injectable bioregulator follows the same structure:
20mg vial
Reconstitute with 2mL bacteriostatic water
2mg per day (20 units on a U-100 syringe)
30 days on, 60 days off
Repeat 2-3x per year
That's it.
One rule: Never exceed 5 bioregulators at the same time.
Simple. Repeatable. Powerful.
Here are the stacks people are using:
Cardiovascular Longevity: Cardiogen + Vesugen + Thymalin
Cognition & Brain Health: Cortagen + Pinealon + Thymalin
Metabolic Support: Pancragen + Livagen + Ovagen
Immune Resilience: Thymagen + Vilon + Thymalin
Men's Health: Testagen + Prostamax + Vesilute
Rejuvenation (Most Popular): Epitalon + Thymalin — 2mg/day for 20 days, 3x per year
Every stack. Same tempo. 2mg daily. 30 on. 60 off.
Why Thymalin shows up in almost every stack:
You'll notice Thymalin appears repeatedly.
That's not an accident.
Your thymus gland — the master regulator of your immune system — starts shrinking after puberty.
By age 50, it's mostly fatty tissue.
Thymalin helps restore thymic function, which improves immune regulation across every system in your body.
It's the foundation bioregulator. Almost everyone benefits from it.
Here's what I'm seeing inside my community:
People who combine peptides AND bioregulators are getting faster, smoother, and more sustained results than those using either alone.
Someone healing an injury with BPC-157 and TB-500?
Add Ventfort for blood flow support → dramatically better outcomes.
Someone on CJC/Ipamorelin for growth hormone optimization?
Add Epitalon → deeper recovery, better sleep.
Transitioning off GLP-1s?
Tesamorelin + thymic bioregulators = way easier maintenance.
The synergy is real.
Your body responds better when the systems underneath are optimized first.
I break all of this down in my new Rumble video.
How Bioregulators Work at the Gene Expression Level (Full Breakdown)
The mechanism. The protocols. The stacks. The real-world application.
If you're serious about longevity — not just "feeling better" but actually restoring your biology from the inside out — this one's for you.
Best,
Lee Maasen
Peptide Community & Member Perks
Studies:
Peptide Bioregulation of Aging: Results and Prospects Anisimov VN, Khavinson VKh. Biogerontology. 2010. This comprehensive review showed that long-term treatment with peptide bioregulators increased mean lifespan by 20-40% in rodents, slowed age-related biomarker changes, and suppressed tumor development. https://pubmed.ncbi.nlm.nih.gov/19830585/
Epithalon Peptide Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells Khavinson VK, Bondarev IE, Butyugov AA. Bulletin of Experimental Biology and Medicine. 2003. This study demonstrated that Epitalon reactivated telomerase in human fibroblast cells and extended telomere length, allowing cells to surpass the Hayflick limit and continue dividing. https://pubmed.ncbi.nlm.nih.gov/12937682/
Peptide Bioregulators: A New Class of Geroprotectors (Clinical Studies) Khavinson VKh, Kuznik BI, Ryzhak GA. Advances in Gerontology. 2013. This review summarized long-term clinical efficacy of peptide bioregulators (Thymalin, Epithalamin, Cortexin, and others) for disease prevention and treatment across different age groups, with special focus on geroprotective applications. https://pubmed.ncbi.nlm.nih.gov/24003726/
35-Year Experience in Research of Peptide Regulation of Aging Khavinson VKh, Anisimov VN. Advances in Gerontology. 2009. This paper presented 35 years of research on peptide bioregulators conducted across laboratories in Russia, USA, UK, Germany, Italy, Spain, and France — including the molecular model of how short peptides interact with gene promoter sites to initiate protein synthesis. https://pubmed.ncbi.nlm.nih.gov/19827673/
Epitalon Increases Telomere Length in Human Cell Lines Through Telomerase Upregulation Araj SK, et al. Biogerontology. 2025. The most recent study showing dose-dependent telomere length extension in normal human cells through hTERT mRNA expression and telomerase enzyme activity upregulation after Epitalon treatment. https://pubmed.ncbi.nlm.nih.gov/40908429/